Gottschalk Lab → University of Pittsburgh, Dept of Immunology

Investigating how immune cells process complex signals at the University of Pittsburgh.

Research efforts focus on (1) modeling signaling-to-transcription in macrophages using computational and experimental approaches, and (2) understanding mechanisms by which alveolar macrophages are programmed by the lung microenvironment. Our overall goal is to understand how macrophage signaling becomes dysregulated and the consequences for tissue homeostasis and inflammation.

Selected Publications

Efficient danger discrimination is enforced by distinct thresholds for NF-kB and MAPK activation, which provide sequential barriers to inflammatory mediator production.

Cell Systems. doi: 10.1016/j.cels.2016.04.016.

Distinct triggering of type I IFN-mediated negative feedback promotes bacteria class-specific regulation of inflammatory response dynamics.

eLIFE. doi: 10.7554/eLife.46836.

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Lab Updates

Meet Our Team

First major grants for the lab! Funding our work related to modeling signaling-to-transcription networks (NIGMS R35) and lung-specific signaling (NHLBI R01). We are recruiting!

Morgan Jackson-Strong successfully completed her comprehensive exam for the Program of Microbiology and Immunology.

Neha Cheemalavagu successfully proposed her thesis through the joint CMU-Pitt PhD Program in Computational Biology.

Neha Cheemalavagu was appointed as an NIH Pre-doctoral Trainee in the Autoimmunity and Immunopathology Training Program.

The Gottschalk lab was awarded a Catalytic Proposal through the Pittsburgh Autoimmunity Center of Excellence in Rheumatology.

Karsen Shoger successfully defended his master’s thesis through the Graduate School of Public Health.

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