Investigating how cells process complex stimuli to inform appropriate immune function at the University of Pittsburgh.

Learn More

Research areas include (1) mechanistic links between phosphorylation dynamics, kinase and transcription factor specificity, and macrophage inflammatory function, (2) lung-specific macrophage signaling, and (3) the influence of aging on macrophage inflammatory response regulation. The ultimate goal of these efforts is to yield insights into disease-specific dysregulation of signaling.

Selected Publications

More Publications

Efficient danger discrimination is enforced by distinct thresholds for NF-kB and MAPK activation, which provide sequential barriers to inflammatory mediator production.

Cell Systems. doi: 10.1016/j.cels.2016.04.016.
View the publication: Distinct NF-kB and MAPK activation thresholds uncouple steady-state microbe sensing from anti-pathogen inflammatory responses

Distinct triggering of type I IFN-mediated negative feedback promotes bacteria class-specific regulation of inflammatory response dynamics.

eLIFE. doi: 10.7554/eLife.46836.
View the publication: IFN-mediated negative feedback supports bacteria class-specific macrophage inflammatory responses

Looking for more?

More Publications
Read more publications

Lab Updates

Meet Our Team

Neha Cheemalavagu successfully proposed her thesis through the joint CMU-Pitt PhD Program in Computational Biology.


Neha Cheemalavagu was appointed as an NIH Pre-doctoral Trainee in the Autoimmunity and Immunopathology Training Program.


The Gottschalk lab was awarded a Catalytic Proposal through the Pittsburgh Autoimmunity Center of Excellence in Rheumatology.


Karsen Shoger successfully defended his master’s thesis through the Graduate School of Public Health.


Get more updates and insights.

Follow Gottschalk Lab on Twitter
Follow Gottschalk Lab on Twitter