Research areas include (1) mechanistic links between phosphorylation dynamics, kinase and transcription factor specificity, and macrophage inflammatory function, (2) lung-specific macrophage signaling, and (3) the influence of aging on macrophage inflammatory response regulation. The ultimate goal of these efforts is to yield insights into disease-specific dysregulation of signaling.
Efficient danger discrimination is enforced by distinct thresholds for NF-kB and MAPK activation, which provide sequential barriers to inflammatory mediator production.