Investigating how immune cells process complex signals at the University of Pittsburgh.
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Selected Publications
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Mechanistic-to-machine learning framework makes global cytokine-induced gene predictions from STAT phosphorylation dynamics.
Cell Systems. DOI: 10.1016/j.cels.2023.12.006.
View the publication: Predicting gene level sensitivity to JAK-STAT signaling perturbation using a mechanistic-to-machine learning framework
Fth1-mScarlet reports monocyte and macrophage state during lung inflammation.
The Journal of Immunology. doi: doi.org/10.4049/jimmunol.2400215.
View the publication: Fth1-mScarlet Reports Monocyte State during Lipopolysaccharide-induced Lung Inflammation
The SOCS family member CISH constrains homeostatic cytokine signaling to maintain alveolar macrophage identity and function
Science Signaling. DOI: 10.1126/scisignal.abe5137.
View the publication: CISH attenuates homeostatic cytokine signaling to promote lung-specific macrophage programming and function
Efficient danger discrimination is enforced by distinct thresholds for NF-kB and MAPK activation, which provide sequential barriers to inflammatory mediator production.
Cell Systems. doi: 10.1016/j.cels.2016.04.016.
View the publication: Distinct NF-kB and MAPK activation thresholds uncouple steady-state microbe sensing from anti-pathogen inflammatory responses
Distinct triggering of type I IFN-mediated negative feedback promotes bacteria class-specific regulation of inflammatory response dynamics.
eLIFE. doi: 10.7554/eLife.46836.
View the publication: IFN-mediated negative feedback supports bacteria class-specific macrophage inflammatory responses