Investigating how cells process complex stimuli to inform appropriate immune function at the University of Pittsburgh.

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Research areas include (1) mechanistic links between phosphorylation dynamics, kinase and transcription factor specificity, and macrophage inflammatory function, (2) lung-specific macrophage signaling, and (3) the influence of aging on macrophage inflammatory response regulation. The ultimate goal of these efforts is to yield insights into disease-specific dysregulation of signaling.

Selected Publications

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Efficient danger discrimination is enforced by distinct thresholds for NF-kB and MAPK activation, which provide sequential barriers to inflammatory mediator production.

Cell Systems. doi: 10.1016/j.cels.2016.04.016.
View the publication: Distinct NF-kB and MAPK activation thresholds uncouple steady-state microbe sensing from anti-pathogen inflammatory responses

Distinct triggering of type I IFN-mediated negative feedback promotes bacteria class-specific regulation of inflammatory response dynamics.

eLIFE. doi: 10.7554/eLife.46836.
View the publication: IFN-mediated negative feedback supports bacteria class-specific macrophage inflammatory responses

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Lab Updates

Meet Our Team

Neha Cheemalavagu successfully proposed her thesis through the joint CMU-Pitt PhD Program in Computational Biology.

01

Neha Cheemalavagu was appointed as an NIH Pre-doctoral Trainee in the Autoimmunity and Immunopathology Training Program.

02

The Gottschalk lab was awarded a Catalytic Proposal through the Pittsburgh Autoimmunity Center of Excellence in Rheumatology.

03

Karsen Shoger successfully defended his master’s thesis through the Graduate School of Public Health.

04

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