Investigating how immune cells process complex signals at the University of Pittsburgh.

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Research efforts focus on (1) modeling signaling-to-transcription in macrophages using computational and experimental approaches,  (2) understanding mechanisms by which lung macrophages are programmed by the tissue microenvironment, and (3) dissecting molecular determinants of macrophage inflammatory function. Our overall goal is to understand how macrophage signaling becomes dysregulated and the consequences for tissue homeostasis and inflammation.

Selected Publications

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Efficient danger discrimination is enforced by distinct thresholds for NF-kB and MAPK activation, which provide sequential barriers to inflammatory mediator production.

Cell Systems. doi: 10.1016/j.cels.2016.04.016.
View the publication: Distinct NF-kB and MAPK activation thresholds uncouple steady-state microbe sensing from anti-pathogen inflammatory responses

Distinct triggering of type I IFN-mediated negative feedback promotes bacteria class-specific regulation of inflammatory response dynamics.

eLIFE. doi: 10.7554/eLife.46836.
View the publication: IFN-mediated negative feedback supports bacteria class-specific macrophage inflammatory responses

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Lab Updates

Meet Our Team

Aaron Francis successfully passed his comprehensive exam for the Integrative Systems Biology program.

01

Undergraduate researchers Aaron Kim, K. Bajpai, and Rushali Patel graduated from the University of Pittsburgh. Best wishes in your future endeavors!

02

Caitlin Strassburg was selected for an appointment on the Cancer Immunology Training Program (CITP) T32. Congratulations Caitlin!

03

Brandon Michalides started a PhD in Immunology at the University of Cincinnati, Children’s Hospital. Best wishes Brandon!

04

We are pleased to announce that Neha Cheemalavagu successfully defended her dissertation! She will be joining the Data Science & Bioinformatics team at Astrazeneca.  Congratulations, Dr. Cheemalavagu!

05

MID Scholar Abigail Sekyere graduated from the University of Pittsburgh as a psychology major. She plans to apply to medical school. Best wishes Abigail!

06

Laura Strube was awarded an Intersect Fellowship from the American Association of Immunologists (AAI). Congratulations Laura!

07

Morgan Jackson-Strong received funding from the NHBLI diversity supplement.

08

Sonia Kruszelnicki successfully passed her comprehensive exam for the Integrative Systems Biology Program and received a T32 in the Autoimmunity and Immunopathology Training Program.

09

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